Framer has 2 (or 1) chance(s) to use their framing ability in a single game.
When they use it, they mess up all the Sheriff results of that night: all the Townie(s) who are interrogated will appear evil to the Sheriff(s), and all the bad guys will appear good. So Framer won't target any specific person but will have a limited chance to mess up all the results of a night.